12-O-Tetradecanoyl phorbol-13-acetate

Synonym: 16561-29-8; TPA; Phorbol 12-myristate 13-acetate

CAS Number: 16561-29-8
PubChem CID: 27924

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

12-O-Tetradecanoyl phorbol-13-acetate, soluble in DMSO and ethanol and insoluble in water, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets NF-κB, and PKC.

Molecular Weight

616.83

Molecular Formula

C₃₆H₅₆O₈

Targets

NF-κB; PKC: 11.7 nM

Form

Lyophilized powder

Purity

>98%

Solubility

DMSO: 94 mg/mL (152.38 mM); Water: insoluble; Ethanol: 94 mg/mL

Applications

12-O-Tetradecanoyl phorbol-13-acetate can be used to help develop potential therapeutic strategies for certain diseases, such as inflammatory disease, fibrotic diseases, and cancer.