The growth of cancer cells is not only affected by its glucose metabolism but also nutrient competition exists between cancer cells and other cells in the tumor microenvironment. Important components of the tumor microenvironment non-tumor cells are divided into tumor-associated fibroblasts, tumor-associated endothelial cells, mesenchymal stem cells, tumor-associated macrophages, dendritic cells, bone marrow-derived tumor suppressor cells, effector T cells, regulatory T cells, etc., the above cells have different effects on the glucose metabolism of tumor cells. Therefore, studying the glucose metabolism relationship between non-tumor cells and tumor cells in the tumor microenvironment is a key step to fully grasping the regulatory mechanism of cancer glucose metabolism. CD BioGlyco can provide an analysis of the relationship of glucose metabolism between cancer cells and the tumor microenvironment.

What We Do

• Role analysis of glucose metabolism in immune response within the tumor microenvironment

Cancer glucose metabolism reprogramming and immune escape are hallmarks of cancer. In the tumor microenvironment, anti-tumor immune effector cells, like cancer cells, rely on the glycolytic pathway to maintain their expansion and anti-tumor functions. Cancer cells remodel the tumor microenvironment through a series of measures, which in turn affect the growth, development, and function of immune cells. We are able to analyze the role of glucose metabolism in the tumor microenvironment on immune responses.

Based on the MOPCGM platform, we can provide the following specific services, including but not limited to:

• Characterization of glucose metabolism in immune cells in the tumor microenvironment
• Glucose metabolomic analysis of the tumor microenvironment
• Role analysis of glucose metabolism reprogramming on effector T cell activation and development
• Role analysis of glucose metabolism reprogramming in tumor-associated macrophage function.

• Regulatory role analysis of microenvironment glucose metabolism on cancer stem cells

Cancer stem cells have a stronger glycolytic phenotype than normal differentiated tumor cells. The metabolism of cancer stem cells is plastic and heterogeneous, and the tumor microenvironment can regulate the glucose metabolism of cancer stem cells and have an impact on the occurrence and development of cancer. We are able to provide an analysis of the regulation of glucose metabolism between the tumor microenvironment and cancer stem cells.

We can provide the following specific services, including but not limited to:

• Analysis of glucose metabolic profiling of cancer stem cell subsets in the tumor microenvironment
• Analysis of the switch of glucose metabolism status in cancer stem cells regulated by the tumor microenvironment

• Regulatory role analysis of cytokines in cancer glucose metabolism

Alterations in the metabolism of some components in the tumor microenvironment can affect the glucose metabolism of cancer cells by secreting a series of extracellular matrix proteins, chemokines, cytokines, and growth factors, and at the same time affect the tumor microenvironment. We are able to provide a functional analysis of glucose metabolism-related substances in the tumor microenvironment.

Applications

Our service can support the following applications, including but not limited to:

• Research on cancer therapeutic strategies targeting the regulation of glucose metabolism between the tumor microenvironment and cancer cells.
• The effect of glucose metabolism intervention on the effect of immunotherapy.
• Development of dual antibodies targeting both glucose metabolism pathways and immune checkpoints.

CD BioGlyco can provide analysis of the role of glucose metabolism in the tumor microenvironment in immune response, cancer stem cell glucose metabolism, and analysis of the glucose metabolism regulation function of cytokines in the tumor microenvironment. Our experienced teams of scientists, researchers, and technicians provide fast turnaround, high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.