The cell surface of Gram-negative bacteria is mainly composed of lipids, carbohydrates, and proteins, which play important roles in molecular conduction and cell-to-cell interactions. In addition, carbohydrates of cell surface molecules can also have a dramatic effect on the virulence of pathogenic bacteria. Lipopolysaccharide (LPS) is an immunostimulatory molecule composed of lipid A, core oligosaccharide, and O antigen, and is also the main component of the outer leaflet of the bacterial outer membrane (OM). It plays an important role in resistance to external stress. Capsular polysaccharides (CPS), composed of tightly packed repeating oligosaccharide subunits, provide bacteria with protection and protection from external threats, such as complement-mediated killing. It is an important virulence factor for several Gram-negative bacteria. Poly-β(1,6)-N-acetyl-d-glucosamine (PNAG) is a surface polysaccharide sometimes called polysaccharide intercellular adhesin. PNAG is involved in biofilm accumulation and immune evasion of some bacteria.
Fig.1 Cell surface components and secretion systems identified in Acinetobacter. (Weber, et al., 2016)
As a professional Polysaccharide Vaccine Development company, CD BioGlyco provides clients with high-quality Polysaccharide Antigen Production services, including Carrier Protein Design, polysaccharide extraction and purification, and polysaccharide and carrier protein conjugation services. A. baumanii has become an increasingly important human pathogen due to the spread of multidrug-resistant strains of antibiotics, attracting increasing scientific attention. LPS, CPS, and PNAG on the surface of A. baumanii undoubtedly become new targets for the development of A. baumanii polysaccharide vaccines due to their unique physiological properties and functions. With advanced equipment and experienced scientists, we provide clients with high-quality A. baumanii lipooligosaccharide (LOS), A. baumanii CPS and A. baumanii PNAG production services.
With complete laboratory equipment and expertise in polysaccharide vaccine development, CD BioGlyco provides high-quality polysaccharide vaccine development services for global enterprises, universities, and research institutes. If you happen to have a polysaccharide vaccine development project in hand, please contact us for more information and a detailed quotation.
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