Properties
Description
A-443654 inhibits the phosphorylation of Akt with anti-inflammatory properties. It targets Akt1, Akt2, Akt3, CDK2, Chk1, CK2, cKIT, ERK2, Flt1, and GSK3β.
Molecular Formula
C24H23N5O
Targets
Akt1: 160 pM (Ki); Akt2: 160 pM (Ki); Akt3: 160 pM (Ki); CDK2: 24 nM (Ki); Chk1: 2.3 nM (Ki); CK2: 2.4 nM (Ki); cKIT: 1.2 μM (Ki); ERK2: 340 μM (Ki); Flt1: 3.6 μM (Ki); GSK3β: 44 μM (Ki)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
A-443654 is employed to research Akt signaling pathways, particularly in cancer cells.
