Akt inhibitor A-443654, Purity ≥98%

Synonym: 552325-16-3; A443654; Akt inhibitor

CAS Number: 552325-16-3
Compound CID: 10172943

Product Size

2 mg; 5 mg; 10 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

A-443654 inhibits the phosphorylation of Akt with anti-inflammatory properties. It targets Akt1, Akt2, Akt3, CDK2, Chk1, CK2, cKIT, ERK2, Flt1, and GSK3β.

Molecular Weight

397.5

Molecular Formula

C₂₄H₂₃N₅O

Targets

Akt1: 160 pM (Ki); Akt2: 160 pM (Ki); Akt3: 160 pM (Ki); CDK2: 24 nM (Ki); Chk1: 2.3 nM (Ki); CK2: 2.4 nM (Ki); cKIT: 1.2 μM (Ki); ERK2: 340 μM (Ki); Flt1: 3.6 μM (Ki); GSK3β: 44 μM (Ki)

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

A-443654 is employed to research Akt signaling pathways, particularly in cancer cells.