Akt inhibitor Afuresertib HCl, Purity ≥98%

Synonym: 1047645-82-8; GSK2110183; GSK 2110183; Akt inhibitor

CAS Number: 1047645-82-8
Compound CID: 46843056

Product Size

5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Afuresertib HCl inhibits the phosphorylation of Akt with anti-inflammatory properties. It targets Akt1, Akt1 E17K mutant, Akt2, Akt3, PKCη, PKCθ, PKC-βI, and ROCK.

Molecular Weight

463.78

Molecular Formula

C₁₈H₁₈Cl₃FN₄OS

Targets

Akt1: 0.08 nM (Ki); Akt1 E17K mutant: 0.2 nM; Akt2: 2 nM (Ki); Akt3: 2.6 nM (Ki); PKCη: 210 nM; PKCθ: 510 nM; PKC-βI: 430 nM; ROCK: 100 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Afuresertib HCl can be used in studies to understand its role in modulating Akt-related cancer progression.

Storage

Store at -20ºC.