Akt inhibitor Afuresertib HCl, Purity ≥98%

Synonym: 1047645-82-8; GSK2110183; GSK 2110183; Akt inhibitor

CAS Number: 1047645-82-8
Compound CID: 46843056

Product Size

5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Afuresertib HCl inhibits the phosphorylation of Akt with anti-inflammatory properties. It targets Akt1, Akt1 E17K mutant, Akt2, Akt3, PKCη, PKCθ, PKC-βI, and ROCK.

Molecular Weight

463.78

Molecular Formula

C₁₈H₁₈Cl₃FN₄OS

Targets

Akt1: 0.08 nM (Ki); Akt1 E17K mutant: 0.2 nM; Akt2: 2 nM (Ki); Akt3: 2.6 nM (Ki); PKCη: 210 nM; PKCθ: 510 nM; PKC-βI: 430 nM; ROCK: 100 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

Afuresertib HCl can be used in studies to understand its role in modulating Akt-related cancer progression.