Akt inhibitor AT7867, Purity ≥98%

Synonym: 857531-00-1; AT-7867; Akt inhibitor

CAS Number: 857531-00-1
Compound CID: 11175137

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AT7867, soluble in DMSO and ethanol and insoluble in water, inhibits the phosphorylation of Akt with anti-inflammatory properties. It targets Akt1, PKA, Akt2, Akt3, c-Src, CDK2, Chk1, EGFR, FGFR3, GSK-3β, and MEK1.

Molecular Weight

337.9

Molecular Formula

C₂₀H₂₀ClN₃

Targets

Akt1: 32 nM; PKA: 20 nM; Akt2: 17 nM; Akt3: 47 nM; c-Src: >1 μM; CDK2: >1 μM; Chk1: >1 μM; EGFR: >1 μM; FGFR3: >1 μM; GSK-3β: >1 μM; MEK1: >1 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 63 mg/mL (186.47 mM); Water: Insoluble; Ethanol: 5 mg/mL (14.79 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

AT7867 can be utilized to explore its dual inhibition of Akt and p70S6 kinase in cancer research.