Akt inhibitor AT7867, Purity ≥98%

Synonym: 857531-00-1; AT-7867; Akt inhibitor

CAS Number: 857531-00-1
Compound CID: 11175137

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AT7867, soluble in DMSO and ethanol and insoluble in water, inhibits the phosphorylation of Akt with anti-inflammatory properties. It targets Akt1, PKA, Akt2, Akt3, c-Src, CDK2, Chk1, EGFR, FGFR3, GSK-3β, and MEK1.

Molecular Weight

337.9

Molecular Formula

C₂₀H₂₀ClN₃

Targets

Akt1: 32 nM; PKA: 20 nM; Akt2: 17 nM; Akt3: 47 nM; c-Src: >1 μM; CDK2: >1 μM; Chk1: >1 μM; EGFR: >1 μM; FGFR3: >1 μM; GSK-3β: >1 μM; MEK1: >1 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 63 mg/mL (186.47 mM); Water: Insoluble; Ethanol: 5 mg/mL (14.79 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AT7867 can be utilized to explore its dual inhibition of Akt and p70S6 kinase in cancer research.

Storage

Store at -20ºC.