Properties
Description
AZD5363, soluble in DMSO and insoluble in ethanol and water, inhibits the phosphorylation of Akt with anti-inflammatory properties. It targets Akt1, Akt2, Akt3, Autophagy, P70S6K, PKA, ROCK1, and ROCK2.
Molecular Formula
C21H25ClN6O2
Targets
Akt1: 3 nM; Akt2: 7 nM; Akt3: 7 nM; Autophagy; P70S6K: 6 nM; PKA: 7 nM; ROCK1: 470 nM; ROCK2: 60 nM
Solubility
DMSO: 79 mg/mL (184.18 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AZD5363 can be used to study the therapeutic effects of Akt inhibition in various cancers.
