Akt inhibitor PF-04691502, Purity ≥98%

Synonym: 1013101-36-4; PF04691502; Akt inhibitor

CAS Number: 1013101-36-4
Compound CID: 25033539

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PF-04691502, soluble in DMSO and insoluble in ethanol and water, inhibits the phosphorylation of Akt with anti-inflammatory properties. It targets PI3Kα, PI3Kγ, mTOR, P-Akt(S473), P-Akt (T308), PI3Kβ, and PI3Kγ.

Molecular Weight

425.5

Molecular Formula

C₂₂H₂₇N₅O₄

Targets

PI3Kα: 1.8 nM (Ki); PI3Kγ: 1.9 nM (Ki); mTOR: 16 nM (Ki); P-Akt(S473): 3.8 nM; P-Akt (T308): 7.5 nM; PI3Kβ: 2.1 nM (Ki); PI3Kγ: 1.6 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 13 mg/mL (30.55 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

PF-04691502 is used to research the inhibition of the PI3K/mTOR pathway and its effects on tumor growth.