Hydrophilic Polysaccharide Alginic Acid Enhances Antacid Property

CD BioGlyco offers an alginic acid analysis based on our Pharmaceutical and Biological Analysis Service, facilitating its application in pharmaceutical formulations for improved therapeutic outcomes. Alginic acid, also known as alginate, is a hydrophilic polysaccharide extracted from brown seaweed through alkaline extraction. It forms a viscous gel when combined with water, found in the cell walls of brown algae. Comprising L-glucuronic acid and D-mannuronic acid residues linked by 1,4-glycosidic bonds, it is not an antacid but enhances antacid formulations due to its unique mechanism. Added to antacid preparations, alginic acid reacts with saliva and sodium bicarbonate to form sodium alginate. When exposed to gastric acid, this alginate precipitates into a foaming gel, creating a pH-neutral barrier against acid reflux. This property boosts the efficacy of drugs treating gastroesophageal reflux disease (GERD). However, alginic acid products are not suitable for peptic ulcer disease (PUD) treatment.

At CD BioGlyco, our alginic acid analysis service is designed to ensure the highest quality and purity standards for alginic acid samples through a series of rigorous tests. Our comprehensive approach includes three main categories of analysis: identification tests, impurities tests, and specific tests.

• Identification test

We use advanced spectroscopic techniques such as fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. These methods allow us to identify characteristic molecular fingerprints and confirm the chemical structure of alginic acid.

• Impurities test

We use high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) to identify and quantify potential contaminants. These methods are highly sensitive and provide precise measurements of impurities, ensuring that the alginic acid meets the required purity levels.

• Specific test

This includes a range of custom tests such as viscosity measurements, molecular weight determination using gel permeation chromatography (GPC), and thermal analysis through differential scanning calorimetry (DSC). Additionally, we perform microbial enumeration tests, loss on drying tests, and pH assessments to ensure the sample's suitability for various applications.

Through these detailed analyses, CD BioGlyco guarantees the integrity and reliability of alginic acid samples. Moreover, we also offer other Pharmaceutical Excipient Analysis Services for clients according to their needs.

Publication Data

Applications

• The alginic acid analysis ensures the quality and purity of alginic acid used as an excipient in pharmaceutical formulations. It verifies the presence of alginic acid and identifies any impurities, guaranteeing the safety and efficacy of medications.
• The alginic acid analysis supports research and development efforts by providing accurate characterization of alginic acid samples, aiding in the development of new products and formulations.

Advantages

• Utilizing state-of-the-art techniques, CD BioGlyco accurately identifies alginic acid and its constituents, ensuring the integrity of the sample.
• Our service includes thorough impurities testing, ensuring that alginic acid samples meet quality standards.
• CD BioGlyco provides specific testing tailored to the client's needs, ensuring that the analysis meets the unique requirements of each application.

At CD BioGlyco, our alginic acid analysis service provides clients with accurate, reliable, and comprehensive analysis solutions, contributing to the quality, safety, and efficacy of their products. Please do not hesitate to contact us if you are interested in our services.