ALK inhibitor ALK-IN-1, Purity ≥98%

Synonym: 1197958-12-5; ALK inhibitor; AP-26113

MDL: MFCD23704187
CAS Number: 1197958-12-5
Compound CID: 57390074

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ALK-IN-1, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against ALK. It targets FER, ROS/ROS1, Abl1, ALK, ARK5, Aurora A, BLK, BRK, BRSK1, BRSK2, BTK.

Molecular Weight

529.01

Molecular Formula

C₂₆H₃₄ClN₆O₂P

Targets

FER: 1.3 nM; ROS/ROS1: 1.9 nM; Abl1: 500 nM; ALK: 0.62 nM; ARK5: 47 nM; AuroraA: 146 nM; BLK: 136 nM; BRK: 4.1 nM; BRSK1: 338 nM; BRSK2: 125 nM; BTK: 673 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 40 mg/mL (75.61 mM); Water: Insoluble; Ethanol: 93 mg/mL (175.8 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

ALK-IN-1 is used to investigate ALK inhibition, which plays a critical role in developing treatments for ALK-positive cancers.