ALK inhibitor CH5424802, Purity ≥98%

Synonym: 1256580-46-7; ALK inhibitor; CH-5424802

MDL: MFCD19440988
CAS Number: 1256580-46-7
Compound CID: 49806720

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CH5424802, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against ALK. It targets ALK, ALK (R1275Q), Abl, Akt1, Akt2, Akt3, ALK(F1174L), AuroraA, CDK1, CDK2, and EGFR.

Molecular Weight

482.6

Molecular Formula

C₃₀H₃₄N₄O₂

Targets

ALK: 1.9 nM; ALK (R1275Q): 3.5 nM; Abl: >5 μM; Akt1: >5 μM; Akt2: >5 μM; Akt3: >5 μM; ALK (F1174L): 1 nM; AuroraA: >5 μM; CDK1: >5 μM; CDK2: >5 μM; EGFR: >5 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 0.5 mg/mL (1.03 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

CH5424802 (also known as alectinib) is a selective inhibitor of ALK, critical for studying treatments targeting ALK-positive NSCLC.