ALK inhibitor Entrectinib, Purity ≥98%

Synonym: 1108743-60-7; ALK inhibitor; RXDX-101; RXDX-101; RXDX-101; NMS E628; NMS-E628; NMSE628

MDL: MFCD28129099
CAS Number: 1108743-60-7
Compound CID: 25141092

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Entrectinib, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against ALK. It targets ALK, ROS1, TrkA, TrkC, and TrkB.

Molecular Weight

560.64

Molecular Formula

C₃₁H₃₄F₂N₆O₂

Targets

ALK; ROS1; TrkA; TrkC; TrkB

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 89 mg/mL (158.74 mM); Water: Insoluble; Ethanol: 67 mg/mL (119.5 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

ALK inhibitor Entrectinib is used to research its ability to inhibit ALK, ROS1, and TRK kinases in various cancers, with implications for targeted oncology therapy.