Properties
Description
HG-14-10-04, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against ALK. It targets ALK, EGFR19del/TM/CS, EGFRLR/TM, and EGFRLR/TM/CS.
Molecular Formula
C29H34ClN7O
Targets
ALK: 20 nM; EGFR19del/TM/CS: 22.6 nM; EGFRLR/TM: 15.6 nM; EGFRLR/TM/CS: 124.5 nM
Solubility
DMSO: 9 mg/mL (16.91 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
HG-14-10-04 aids in studying the inhibition of ALK, contributing to potential cancer treatment strategies.