ALK inhibitor LDK-378, Purity ≥98%

Synonym: 1032900-25-6; ALK inhibitor; LDK378; LDK 378

MDL: MFCD26142648
CAS Number: 1032900-25-6
Compound CID: 57379345

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LDK-378, soluble in warmed DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against ALK. It targets IGF-1R, Insulin receptor, Abl, Akt, ALK, Aurora A, BTK, c-Kit, c-Met, CDK2, and CDK4.

Molecular Weight

558.14

Molecular Formula

C₂₈H₃₆ClN₅O₃S

Targets

IGF-1R: 8 nM; Insulin receptor: 7 nM; Abl: 1.25 μM; Akt: >10 μM; ALK: 0.2 nM; AuroraA: 0.66 nM; BTK: 3.36 nM; c-Kit: 1.28 μM; c-Met: 3.17 μM; CDK2: 3.97 μM; CDK4: 4.72 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 18 mg/mL (32.25 mM); Water: Insoluble; Ethanol: 3 mg/mL (5.37 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

LDK-378 (now known as ceritinib) targets and inactivates ALK, particularly in research on ALK-positive NSCLC.