ALK inhibitor PF-06463922, Purity ≥98%

Synonym: 1454846-35-5; ALK inhibitor; PF 06463922; PF06463922

MDL: MFCD28144520
CAS Number: 1454846-35-5
Compound CID: 71731823

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PF-06463922, soluble in warmed DMSO and warmed ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against ALK. It targets ALK, ROS1, ALK (L1196M), DCAMKL2(DCK2), EGFR(ErbB1)T790M, EGFR(ErbB1)T790ML858R, EPHA1, FER, FES(FPS), FRK(PTK5), and IGF1R.

Molecular Weight

406.41

Molecular Formula

C₂₁H₁₉FN₆O₂

Targets

ALK: <0.07 nM (Ki); ROS1: <0.02 nM (Ki); ALK (L1196M): 0.07 nM (Ki); DCAMKL2 (DCK2): 370 nM; EGFR (ErbB1) T790M: 319 nM; EGFR (ErbB1) T790ML858R: 245 nM; EPHA1: 375 nM; FER: 3.3 nM; FES (FPS): 6 nM; FRK (PTK5): 53 nM; IGF1R: 296 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 70 mg/mL (172.23 mM); Water: Insoluble; Warmed ethanol: 26 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

PF-06463922, also known as lorlatinib, is studied for its effectiveness in overcoming resistance in ALK-positive cancers.