ALK inhibitor SB 525334, Purity ≥98%

Synonym: 356559-20-1; SB-525334; SB 525334; SB525334; 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline; 6-[2-tert-BUTYL-5-(6-METHYL-PYRIDIN-2-YL)-1H-IMIDAZOL-4-YL]-QUINOXALINE; ALK inhibitor

MDL: MFCD11045307
CAS Number: 356559-20-1
Compound CID: 9967941

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SB 525334, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against ALK. It targets TGFβR1 (ALK5).

Molecular Weight

343.4

Molecular Formula

C₂₁H₂₁N₅

Targets

TGFβR1 (ALK5): 14.3 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 67 mg/mL (195.09 mM); Water: Insoluble; Ethanol: 67 mg/mL (195.09 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

SB 525334 can be used to investigate its selective inhibition of TGF-β receptor type I and its potential therapeutic applications.

Storage

Store at -20ºC.