ALK inhibitor, TAE684, Purity ≥98%

Synonym: 761439-42-3; NVP-TAE684; TAE-684; 5-Chloro-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine; ALK inhibitor

MDL: MFCD11977634
CAS Number: 761439-42-3
Compound CID: 16038120

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TAE684, soluble in DMSO and insoluble in water and ethanol, is an effective autophagy signaling inhibitor, that has the ability to prevent the pathway of LRRK1 by inhibiting Protein Tyrosine Kinases. The molecular weight of the compound is 614.2, and its molecular formula is C₃₀H₄₀ClN₇O₃S. It targets the ALK (Cell-free assay).

Molecular Weight

614.2

Molecular Formula

C₃₀H₄₀ClN₇O₃S

Targets

ALK (Cell-free assay)

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 3 mg/mL (4.88 mM); Water: insoluble; Ethanol: insoluble; In vivo: 30% PEG400 + 0.5% Tween80 + 5% propylene glycol, pH 4, 9 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

TAE684 can be used for its effects in ALK-positive cancers, such as non-small cell lung cancer (NSCLC).