Properties
Description
HTH-01-015, soluble in warmed DMSO and ethanol and insoluble in water, downregulates metabolic and energy homeostasis pathways, affecting cellular energy balance and potentially influencing cancer and metabolic disorders. It targets NUAK1 and NUAK2.
Molecular Formula
C26H28N8O
Targets
NUAK1: 100 nM; NUAK2: >10 μM
Solubility
Warmed DMSO: 54 mg/mL (115.24 mM); Water: Insoluble; Ethanol: 28 mg/mL (59.75 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
HTH-01-015 is employed to inhibit AMPK and investigate its effects on cellular pathways.