Properties
Description
PF-06409577, soluble in DMSO and ethanol and insoluble in water, downregulates metabolic and energy homeostasis pathways, affecting cellular energy balance and potentially influencing cancer and metabolic disorders. It targets AMPK α1β1γ1.
Molecular Formula
C19H16ClNO3
Targets
AMPK α1β1γ1: 7 nM (EC50)
Solubility
DMSO: 63 mg/mL (184.32 mM); Water: Insoluble; Ethanol: 63 mg/mL (184.32 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
PF-06409577 is used in research focusing on the selective inhibition of protein tyrosine phosphatase 1B (PTP1B) for metabolic diseases.
