Properties
Description
WZ4003, soluble in DMSO and insoluble in ethanol and water, downregulates metabolic and energy homeostasis pathways, affecting cellular energy balance and potentially influencing cancer and metabolic disorders. It targets NUAK1 and NUAK2.
Molecular Formula
C25H29ClN6O3
Targets
NUAK1: 20 nM; NUAK2: 100 nM
Solubility
DMSO: 7 mg/mL (14.08 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
WZ4003 can be used to investigate the inhibition of salt-inducible kinases (SIKs) in immune and metabolic disorders.
