The pentose phosphate pathway is an important step in glucose metabolism. In cancer cells, the pentose phosphate pathway is up-regulated, and cancer cells enhance nucleic acid synthesis and counteract oxidative stress through the up-regulated pentose phosphate pathway, which is responsible for the drug resistance of cancer cells. Therefore, it is of great significance to study the genomic information related to the pentose phosphate pathway and explore the regulatory mechanism of the up-regulation of the pentose phosphate pathway for cancer treatment. CD BioGlyco can provide genomic information analysis services related to the cancer pentose phosphate pathway, laying the foundation for the development of cancer treatment strategies targeting the pentose phosphate pathway.

Fig. 1 The pentose phosphate pathway (Patra KC, et al.,2014)

What We Do

• PPP related gene expression analysis

We can provide high-throughput sequencing services for PPP related genes, and provide customers with customized analysis services based on the sequencing results.

Based on the MOPCGM platform, we can provide the following specific services, including but not limited to:

GO and KEGG pathway analysis, differential genetic screening, Kaplan-Meier survival analysis, genome-wide association study, etc.

• Functional analysis of single nucleotide polymorphisms in PPP related genes

Different genotypes of single nucleotide polypeptides in genes encoding PPP related enzymes have different effects on the occurrence and development of cancer. We can provide analysis of single nucleotide polypeptides of PPP related enzyme encoding genes to help customers explore the relationship between single-nucleotide polymorphisms of PPP related enzyme encoding genes and cancer prognosis and recurrence, and promote the clinical application of research results.

• PPP related gene function analysis

We can predict the function of PPP related genes based on the bioinformatics methods provided by the MOPCGM platform and analyze the functions of PPP related genes through gene editing technology.

Our Advantages

• Based on our MOPCGM platform, the combined analysis of genome and metabolome can more effectively reveal the molecular mechanism of the reprogramming process of glucose metabolism.
• Based on our MOPCGM platform, the combined analysis of genome and protein makes the study of gene function more in-depth.
• Dedicated PPP related genomics research, with a strong research purpose, helps customers screen valuable information and obtain research results faster.

Applications

• To explore the potential of pentose phosphate pathway related gene mutations as cancer diagnostic and prognostic markers.
• Search for gene mutation targets related to the pentose phosphate pathway with cancer therapeutic potential.
• To explore the relationship between cancer cell drug resistance and the pentose phosphate pathway.

CD BioGlyco can provide bioinformatics analysis services such as detection services for pentose phosphate pathway related gene mutations, differential gene expression analysis, and signal pathway enrichment analysis. Our experienced teams of scientists, researchers, and technicians provide fast turnaround, high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.

Reference:

1. Patra KC, Hay N. The pentose phosphate pathway and cancer. Trends Biochem Sci. 2014 Aug; 39 (8): 347-54.