CD BioGlyco has professional glycomedicine development teams and first-class carbohydrate-based glycomedicine development platform, which provide customers with unparalleled glycomedicine development services and complete after-sales services.

The Importance of Animal-derived Carbohydrate-based Glycomedicines

Animals are one of the important sources of natural polysaccharides. Animal-derived carbohydrate-based glycomedicines play an important role in the fields of pharmacy, medicine, biology, and materials. Chitosan/chitin, chondroitin sulfate, and hyaluronic acid are several major animal polysaccharides. Oligomers from partial acid hydrolysis of chitin and chitosan were recognized for their bioactivity, including hemostatic action, anti-inflammatory effect, antitumoral, antibacterial, and fungicidal properties, eliciting chitinase, and regulating plant growth. Growing evidence reveals the previously less or unperceived functions of chondroitin sulfate, for example being a key molecule of the brain extracellular matrix, regulating the cell adhesion, proliferation and migration during wound healing. In addition, hyaluronic acid is an essential component of the extracellular matrix, mediating cellular signaling, wound repair, morphogenesis, and matrix organization. Therefore, it has become an inevitable trend to increase a deeper understanding of animal-derived carbohydrate-based glycomedicine development.

Fig.1 The mains cross-linking reactions using chitosan (Brasselet, et al., 2019).

Animal-derived Carbohydrate-based Glycomedicine Development Services

At CD BioGlyco, we pay attention to every detail in carbohydrate-based glycomedicine development and strive for perfection in every process, evidenced by our many years of successful experience. We provide services for the isolation, purification, biological activity assay, and structural identification of animal-derived natural carbohydrates, such as chitosan, chondroitin, and hyaluronic acids. Moreover, we are able to modify the groups of polysaccharides employing efficient methods. Our methods include but are not limited to:

• Modification of carboxylic groups of animal-derived carbohydrates by amidation, Ugi condensation, and esterification
• Modification of chitosan on amino groups includes acetylation, quaternization, Schiff base reaction, graft copolymerization (by chemical cross-linking, free radicals methods, radiation methods, and enzymatic grafting methods), and carboxymethylation.
• Modification of hyaluronic acids on the hydroxyl groups (both primary and secondary) includes etherification, esterification, hemiacetal crosslinking, carbamate formation, and selective oxidation.

Applications

• Special absorption of template molecules mimicking natural recognition materials such as antibodies for diagnostics.
• Regenerative medicine.
• Tissue-engineering applications.

Advantages of Us

• Significantly higher imprinting efficiency and specificity for template protein.
• The unique physicochemical and biochemical properties of functional carbohydrates are preserved.
• Advanced modification technology.

CD BioGlyco has accumulated extensive experience in the development of animal-derived carbohydrates for glycomedicine development. If you are interested in our services, please contact us for more details.

Reference:

1. Brasselet, C.; et al. Modification of chitosan for the generation of functional derivatives. Applied Sciences. 2019, 9(7): 1321.