Properties
Description
AP521 inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT1A receptor, 5-HT1A receptor, 5-HT1B receptor, 5-HT1B receptor, 5-HT1D receptor, 5-HT5A receptor, and 5-HT7 receptor.
Molecular Formula
C20H19ClN2O3S
Targets
5-HT1A receptor: 94 nM (IC50, in human); 5-HT1A receptor: 135 nM (IC50, in rat); 5-HT1B receptor: 254 nM (IC50, in rat); 5-HT1B receptor: 5530 nM (IC50, in human); 5-HT1D receptor: 418 nM (IC50, in human); 5-HT5A receptor: 422 nM (IC50, in human); 5-HT7 receptor: 198 nM (IC50, in rat)
Applications
AP521 can be used for its potent anxiolytic-like effects.
