Properties
Description
AP521 inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT1A receptor, 5-HT1A receptor, 5-HT1B receptor, 5-HT1B receptor, 5-HT1D receptor, 5-HT5A receptor, and 5-HT7 receptor.
Molecular Formula
C20H19ClN2O3S
Targets
5-HT1A receptor: 94 nM (IC50, in human); 5-HT1A receptor: 135 nM (IC50, in rat); 5-HT1B receptor: 254 nM (IC50, in rat); 5-HT1B receptor: 5530 nM (IC50, in human); 5-HT1D receptor: 418 nM (IC50, in human); 5-HT5A receptor: 422 nM (IC50, in human); 5-HT7 receptor: 198 nM (IC50, in rat)
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AP521 can be used for its potent anxiolytic-like effects.
Storage
Store at -20°C, and keep desiccated.
