Properties
Description
Aprepitant (MK-0869), soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets neurokinin-1 receptor (cell-free assay).
Molecular Formula
C23H21F7N4O3
Targets
Neurokinin-1 receptor (Cell-free assay): 0.1 nM
Solubility
DMSO: 96 mg/mL (179.63 mM); Water: insoluble; Ethanol: 14 mg/mL (26.19 mM)
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Aprepitant (MK-0869) can be used in the prevention of chemotherapy-induced nausea and vomiting.
Storage
Store at -20℃, and keep desiccated.
