Aprepitant

Synonym: 170729-80-3; MK0869; MK-869; L-754030; Emend

CAS Number: 170729-80-3
PubChem CID: 135413536

Product Size

2 mg; 5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Aprepitant (MK-0869), soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets neurokinin-1 receptor (cell-free assay).

Molecular Weight

534.4

Molecular Formula

C₂₃H₂₁F₇N₄O₃

Targets

Neurokinin-1 receptor (Cell-free assay): 0.1 nM

Form

Lyophilized powder

Purity

>98%

Solubility

DMSO: 96 mg/mL (179.63 mM); Water: insoluble; Ethanol: 14 mg/mL (26.19 mM)

Applications

Aprepitant (MK-0869) can be used in the prevention of chemotherapy-induced nausea and vomiting.