Properties
Description
KU-55933, soluble in DMSO and insoluble in ethanol and water, interferes with DNA damage response and repair processes, enhancing the sensitivity of cancer cells. It targets DNA-PK, mTOR, ATM, ATR, PI3K, and PI4K.
Molecular Formula
C21H17NO3S2
Targets
DNA-PK: 2.5 μM; mTOR: 9.3 μM; ATM: 12.9 μM; ATR: >100 μM; PI3K: 16.6 μM; PI4K: >100 μM
Solubility
DMSO: 29 mg/mL (73.33 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
KU-55933 is utilized to investigate ATM kinase inhibition in cancer research and DNA damage response.
