ATM inhibitor-1, Purity ≥98%

Synonym: 2135639-94-8; ATM Inhibitor-1; CHEMBL4218854; 6-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-N-methyl-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide; SCHEMBL19384258; ATM-ATR inhibitor

CAS Number: 2135639-94-8
Compound CID: 130453737

Product Size

1 mg; 5 mg; 10 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ATM inhibitor-1 interferes with DNA damage response and repair processes, enhancing the sensitivity of cancer cells. It targets ATM, ATM, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.

Molecular Weight

492.61

Molecular Formula

C₂₇H₃₆N₆O₃

Targets

ATM: 0.7 nM; ATM: 2.8 nM (IC₅₀, cellular assay); DNAPK: 2.8 μM; mTOR: 21 μM; PI3Kα: 3.8 μM; PI3Kβ: 10.3 μM; PI3Kδ: 0.73 μM; PI3Kγ: 3 μM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

ATM inhibitor-1 is utilized to study the inhibition of ataxia-telangiectasia mutated (ATM) in DNA damage response research.

Storage

Store at -20ºC.