Properties
Description
Brefeldin A, soluble in DMSO and insoluble in ethanol and water, specifically hinders the activity of ATPase enzymes, thereby disrupting the process of ATP hydrolysis, which is critical for energy conversion and cellular functions. It targets ATPase (HCT 116).
Molecular Formula
C16H24O4
Targets
ATPase (HCT 116): 0.2 μM
Solubility
DMSO: 4 mg/mL (14.26 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Brefeldin A functions as an ATPase inhibitor in research on intracellular trafficking and Golgi apparatus function, investigating how it disrupts protein transport.