Properties
Description
ENMD-2076 tartrate, soluble in warmed DMSO and insoluble in water and ethanol, inhibits Aurora kinases, which play crucial roles in cell division by controlling chromosome segregation and cytokinesis. It targets Aurora A, FGFR1, FGFR2, and Flt-4.
Molecular Formula
C25H31N7O6
Targets
Aurora A: 1.86 nM; FGFR1: 92.7 nM; FGFR2: 70.8 nM; Flt-4: 15.9 nM
Solubility
Warmed DMSO: 86 mg/mL (163.63 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
ENMD-2076 tartrate is used to explore its effects as a multi-kinase inhibitor, particularly targeting Aurora A and angiogenesis-related kinases.
