Aurora kinase inhibitor MK-8745, Purity ≥98%

Synonym: 885325-71-3; MK-8745; MK8745; (3-Chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone; (3-Chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone; (3-Chloro-2-fluorophenyl)-[4-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]piperazin-1-yl]methanone; Aurora kinase inhibitor

MDL: MFCD28009367
CAS Number: 885325-71-3
Compound CID: 11676373

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

MK-8745, soluble in DMSO and ethanol and insoluble in water, is an Aurora kinase inhibitor that disrupts cell division processes. It targets Aurora A and Aurora B.

Molecular Weight

431.91

Molecular Formula

C₂₀H₁₉ClFN₅OS

Targets

Aurora A: 0.6 nM; Aurora B: 280 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 81 mg/mL (187.53 mM); Water: Insoluble; Ethanol: 1 mg/mL (2.31 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

MK-8745 can be employed to investigate the selective inhibition of Aurora kinase A and its role in cell cycle arrest.