Aurora kinase inhibitor MLN8054, Purity ≥98%

Synonym: MLN8054; 869363-13-3; MLN-8054; MLN 8054; 4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid; 4-((9-Chloro-7-(2,6-difluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)benzoic acid; BX854EHD63; Aurora kinase inhibitor

CAS Number: 869363-13-3
Compound CID: 11712649

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

MLN8054, soluble in DMSO and insoluble in ethanol and water, is an Aurora kinase inhibitor that disrupts cell division processes. It targets Aurora B, LCK, Aurora A, CaMKII, CDK1, CDK2E, Chk1, Chk2, CK2, PKA, and PKC.

Molecular Weight

476.9

Molecular Formula

C₂₅H₁₅ClF₂N₄O₂

Targets

Aurora B: 172 nM; LCK: 3.2 μM; Aurora A: 4 nM; CaMKII: >100 μM; CDK1: >100 μM; CDK2E: >100 μM; Chk1: >100 μM; Chk2: 28 μM; CK2: 20.5 μM; PKA: 19 μM; PKC: >100 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 91 mg/mL (190.82 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

MLN8054 serves in studying the inhibition of Aurora kinase A to understand its impact on mitosis in cancer cells.