Properties
Description
MLN8237, soluble in DMSO and insoluble in ethanol and water, is an Aurora kinase inhibitor that disrupts cell division processes. It targets Aurora A and Aurora B.
Molecular Formula
C27H20ClFN4O4
Targets
Aurora A: 1.2 nM; Aurora B: 396.5 nM
Solubility
DMSO: 23 mg/mL (44.32 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
MLN8237, also known as alisertib, is used to explore the influence of Aurora kinase A inhibition on tumor growth.