Aurora kinase inhibitor MLN8237, Purity ≥98%

Synonym: Alisertib; 1028486-01-2; MLN8237; MLN-8237; MLN 8237; MLN8237 (Alisertib); 4-((9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)-2-methoxybenzoic acid; Aurora kinase inhibitor

MDL: MFCD16621243
CAS Number: 1028486-01-2
Compound CID: 24771867

Product Size

5 mg; 10 mg; 50 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

MLN8237, soluble in DMSO and insoluble in ethanol and water, is an Aurora kinase inhibitor that disrupts cell division processes. It targets Aurora A and Aurora B.

Molecular Weight

518.9

Molecular Formula

C₂₇H₂₀ClFN₄O₄

Targets

Aurora A: 1.2 nM; Aurora B: 396.5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 23 mg/mL (44.32 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

MLN8237, also known as alisertib, is used to explore the influence of Aurora kinase A inhibition on tumor growth.