Aurora kinase inhibitor PHA-680632, Purity ≥98%

Synonym: PHA-680632; 398493-79-3; N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide; PHA680632; N-(2,6-Diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide; 65W8KZU2A4; Aurora kinase inhibitor

CAS Number: 398493-79-3
Compound CID: 11249084

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PHA-680632, soluble in DMSO and insoluble in ethanol and water, is an Aurora kinase inhibitor that disrupts cell division processes. It targets Aurora B, Aurora C, Aurora A, FGFR1, FLT3, LCK, PLK1, STLK2, VEGFR2, and VEGFR3.

Molecular Weight

501.6

Molecular Formula

C₂₈H₃₅N₇O₂

Targets

Aurora B: 135 nM; Aurora C: 120 nM; Aurora A: 27 nM; FGFR1: 390 nM; FLT3: 820 nM; LCK: 1950 nM; PLK1: 780 nM; STLK2: 5500 nM; VEGFR2: 1920 nM; VEGFR3: 1000 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 91 mg/mL (181.41 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

PHA-680632 is utilized to understand the therapeutic potential of targeting Aurora kinases in oncology.