Aurora kinase inhibitor VX-680, Purity ≥98%

Synonym: Tozasertib; 639089-54-6; VX-680; MK-0457; VX 680; MK 0457; VX680; Aurora kinase inhibitor

MDL: MFCD13185152
CAS Number: 639089-54-6
Compound CID: 5494449

Product Size

25 mg; 50 mg; 100 mg; 250 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

VX-680, soluble in DMSO and insoluble in ethanol and water, is an Aurora kinase inhibitor that disrupts cell division processes. It targets Aurora A, Aurora B, Aurora C, Bcr-Abl, and FLT3.

Molecular Weight

464.6

Molecular Formula

C₂₃H₂₈N₈OS

Targets

Aurora A: 0.6 nM (Ki app); Aurora B: 18 nM (Ki app); Aurora C: 4.6 nM (Ki app); Bcr-Abl: 30 nM (Ki); FLT3: 30 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 90 mg/mL (193.71 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

VX-680, also known as MK-0457, is used to study the inhibition of Aurora kinases in cancer therapy.