Aurora kinase inhibitor ZM-447439, Purity ≥98%

Synonym: 331771-20-1; ZM-447439; ZM 447439; ZM447439; N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE; N-(4-((6-Methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)benzamide; TCMDC-125873; Aurora kinase inhibitor

CAS Number: 331771-20-1
Compound CID: 9914412

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ZM-447439, soluble in DMSO and insoluble in ethanol and water, is an Aurora kinase inhibitor that disrupts cell division processes. It targets Aurora B, LCK, Aurora A, CDK1, CDK2, CDK4, cFLT2, Chk1, FAK, IKK1, and IKK2.

Molecular Weight

513.6

Molecular Formula

C₂₉H₃₁N₅O₄

Targets

Aurora B: 130 nM; LCK: 880 nM; Aurora A: 110 nM; CDK1: >10 μM; CDK2: >10 μM; CDK4: >10 μM; cFLT2: >10 μM; Chk1: >10 μM; FAK: >10 μM; IKK1: >10 μM; IKK2: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 90 mg/mL (175.23 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

ZM-447439 can be employed to study the specific inhibition of Aurora B kinase and its impact on mitosis.

Storage

Store at -20ºC.