Properties
Description
SMER28, soluble in DMSO and ethanol and insoluble in water, is an effective autophagy signaling inhibitor, that has the ability to prevent the pathway of autophagy. The molecular weight of the compound is 264.12, and its molecular formula is C11H10BrN3.
Molecular Formula
C11H10BrN3
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO: 49 mg/mL (185.52 mM); Water: insoluble; Ethanol: 49 mg/mL (185.52 mM); In vivo: 2% DMSO + 30% PEG 300 + ddH2O, 14 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
SMER28 plays a key role in activating the mTOR pathway in a manner that promotes cellular degradation of damaged proteins and organelles.
