Bcl-2 antagonist A-1155463, Purity ≥98%

Synonym: 1235034-55-5; A-1155463; A1155463; 2-[8-(1,3-Benzothiazol-2-Ylcarbamoyl)-3,4-Dihydroisoquinolin-2(1H)-Yl]-5-(3-{4-[3-(dimethylamino)prop-1-Yn-1-Yl]-2-fluorophenoxy}propyl)-1,3-thiazole-4-carboxylic acid; Bcl-2 antagonist

MDL: MFCD29924714
CAS Number: 1235034-55-5
Compound CID: 59447577

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

A-1155463, soluble in DMSO and insoluble in ethanol and water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets BCL-XL, Bcl-w, Bcl-2, and Mcl-1.

Molecular Weight

669.79

Molecular Formula

C₃₅H₃₂FN₅O₄S₂

Targets

BCL-XL: 440 nM (Ki); Bcl-w; Bcl-2; Mcl-1

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 78 mg/mL (116.45 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

A-1155463 can be used to study its functional contribution to cell survival in physiological and pathophysiological conditions.

Storage

Store at -20ºC.