Bcl-2 antagonist BH3I-1, Purity ≥98%

Synonym: 300817-68-9; BH3I-1; 5-[(4-Bromophenyl)methylene]-a-(1-methylethyl)-4-oxo-2-thioxo-3-thiazolidineacetic acid; 2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-methylbutanoic acid; Bcl-2 antagonist

CAS Number: 300817-68-9
Compound CID: 6090108

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BH3I-1, soluble in warmed DMSO and warmed ethanol and insoluble in water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells.

Molecular Weight

400.3

Molecular Formula

C₁₅H₁₄BrNO₃S₂

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 56 mg/mL (139.89 mM); Water: Insoluble; Warmed ethanol: 11 mg/mL (27.47 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

BH3I-1 can be used to selectively inhibit Bcl-2 to study its effects on apoptosis and its potential as a therapeutic target.

Storage

Store at -20ºC.