Bcl-2 inhibitor A-1210477, Purity ≥98%

Synonym: 1668553-26-1; A-1210477; 7-(5-((4-(4-(N,N-Dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid; Bcl-2 inhibitor

MDL: MFCD28399118
CAS Number: 1668553-26-1
Compound CID: 66575373

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

A-1210477, soluble in warmed DMSO and insoluble in water and ethanol, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Mcl-1.

Molecular Weight

850.04

Molecular Formula

C₄₆H₅₅N₇O₇S

Targets

Mcl-1: 26.2 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 3 mg/mL (3.52 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

A-1210477 can be used to assess its role in sustaining cancer cell viability and resistance to chemotherapy.