Bcl-2 inhibitor A-1331852, Purity ≥98%

Synonym: 1430844-80-6; A1331852; A-1331852; 3-[1-(1-Adamantylmethyl)-5-methylpyrazol-4-yl]-6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]pyridine-2-carboxylic acid; Bcl-2 inhibitor

MDL: MFCD30532662
CAS Number: 1430844-80-6
Compound CID: 71565985

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

A-1331852, soluble in DMSO and insoluble in ethanol and water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets BCL-XL, Bcl-w, Bcl-2, and Mcl-1.

Molecular Weight

658.82

Molecular Formula

C₃₈H₃₈N₆O₃S

Targets

BCL-XL: <0.01 nM (Ki); Bcl-w: 4 nM (Ki); Bcl-2: 6 nM (Ki); Mcl-1: 142 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 91 mg/mL (138.12 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

A-1331852 can be used to explore its role in apoptosis and potential as a therapeutic target for cancer treatment.