Bcl-2 inhibitor ABT-737, Purity ≥98%

Synonym: 852808-04-9; ABT-737; ABT 737; ABT737; UNII-Z5NFR173NV; 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide; Bcl-2 inhibitor

MDL: MFCD12756212
CAS Number: 852808-04-9
Compound CID: 11228183

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ABT-737, soluble in DMSO and insoluble in ethanol and water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Bcl-2, Bcl-B, Bcl-w, Bcl-xL, Bfl-1, and Mcl-1.

Molecular Weight

813.4

Molecular Formula

C₄₂H₄₅ClN₆O₅S₂

Targets

Bcl-2: 30.3 nM; Bcl-B: 1.82 μM (EC₅₀); Bcl-w: 197.8 nM (EC₅₀); Bcl-xL: 78.7 nM (EC₅₀); Bfl-1: >10 uM (EC₅₀); Mcl-1: >10 uM (EC₅₀)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 92 mg/mL (113.1 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

ABT-737 can be used to study the role of BCL-2 family proteins in cancer and to develop combination therapies.