Bcl-2 inhibitor AT101 acetic acid, Purity ≥98%

Synonym: 12542-36-8; 866541-93-7; Gossypol acetic acid; Gossypol-acetic acid; Gossypol acetate; Acetate gossypol; AT101; 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde acetate salt; Bcl-2 inhibitor

MDL: MFCD00058385
CAS Number: 866541-93-7
Compound CID: 227456

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AT101 acetic acid, soluble in DMSO and ethanol and insoluble in water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Mcl-1, Bcl-2, and Bcl-xL.

Molecular Weight

578.61

Molecular Formula

C₃₀H₃₀O₈.C₂H₄O₂

Targets

Mcl-1: 0.18 μM (Ki); Bcl-2: 0.32 μM (Ki); Bcl-xL: 0.48 μM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 108 mg/mL (186.65 mM); Water: Insoluble; Ethanol: 83 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AT101 acetic acid can be applied to research involving the inhibition of Bcl-2 family proteins and its effects on inducing apoptosis in cancer cells.

Storage

Store at -20ºC.