Bcl-2 inhibitor Sabutoclax, Purity ≥98%

Synonym: 1228108-65-3; Sabutoclax; BI-97C1; 39Y89ZRK34; (1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2'-binaphthalene]-5,5'-dicarboxamide; 2,3,5-Trihydroxy-7-methyl-N-[(2R)-2-phenylpropyl]-6-[1,6,7-trihydroxy-3-methyl-5-[[(2R)-2-phenylpropyl]carbamoyl]naphthalen-2-yl]naphthalene-1-carboxamide; Bcl-2 inhibitor

CAS Number: 1228108-65-3
Compound CID: 46236925

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

Sabutoclax, soluble in warmed DMSO and warmed ethanol and insoluble in water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Mcl-1, Bcl-xL, Bcl-2, and Bcl-1.

Molecular Weight

700.78

Molecular Formula

C₄₂H₄₀N₂O₈

Targets

Mcl-1: 0.20 μM; Bcl-xL: 0.31 μM; Bcl-2: 0.32 μM; Bcl-1: 0.62 μM

Form

Lyophilized powder

Purity

Solubility

Warmed DMSO: 93 mg/mL (132.7 mM); Water: Insoluble; Warmed ethanol: 50 mg/mL (71.34 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Sabutoclax can be used to study its role of Bcl-2 family proteins in anti-apoptotic signaling in various cellular models.