Bcl-2 inhibitor TW-37, Purity ≥98%

Synonym: 877877-35-5; N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide; tw 37; N-(4-((2-(tert-Butyl)phenyl)sulfonyl)phenyl)-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide; Bcl-2 inhibitor

MDL: MFCD17010275
CAS Number: 877877-35-5
Compound CID: 11455910

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TW-37, soluble in DMSO and ethanol and insoluble in water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Mcl-1, Bcl-2, and Bcl-xL.

Molecular Weight

573.7

Molecular Formula

C₃₃H₃₅NO₆S

Targets

Mcl-1: 0.26 μM (Ki); Bcl-2; Bcl-xL: 1.11 μM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 110 mg/mL (191.73 mM); Water: Insoluble; Ethanol: 4 mg/mL (6.97 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

TW-37 can be used to research inducing apoptosis in various tumor types, including pancreatic cancer, multiple myeloma, and prostate cancer.

Storage

Store at -20ºC.