Bcl-2 inhibitor UMI-77, Purity ≥98%

Synonym: 518303-20-3; UMI-77; UMI77; 2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid; 2-((4-((4-Bromophenyl)sulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid; Bcl-2 inhibitor

MDL: MFCD03471890
CAS Number: 518303-20-3
Compound CID: 992586

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

UMI-77, soluble in DMSO and ethanol and insoluble in water, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Mcl-1.

Molecular Weight

468.34

Molecular Formula

C₁₈H₁₄BrNO₅S₂

Targets

Mcl-1: 490 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 92 mg/mL (196.43 mM); Water: Insoluble; Ethanol: 92 mg/mL (196.43 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

UMI-77 can be used to explore its function and therapeutic potential in cancer research.

Storage

Store at -20ºC.