Bcl-2 inhibitor Venetoclax, Purity ≥98%

Synonym: 1257044-40-8; Venetoclax; ABT-199; Venclexta; GDC-0199; ABT199; ABT 199; 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; Bcl-2 inhibitor

MDL: MFCD23160052
CAS Number: 1257044-40-8
Compound CID: 49846579

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Venetoclax, soluble in warmed DMSO and insoluble in water and ethanol, specifically inhibits the function of the anti-apoptotic proteins, thereby promoting apoptosis in cancer cells. It targets Bcl-2, Bcl-xL, Bcl-w, and Mcl-1.

Molecular Weight

868.44

Molecular Formula

C₄₅H₅₀ClN₇O₇S

Targets

Bcl-2: 444 nM (Ki); Bcl-xL; Bcl-w; Mcl-1

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 93 mg/mL (107.08 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Venetoclax can be used to research the therapy in certain types of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML).

Storage

Store at -20ºC.