Bcr-Abl inhibitor AZD0530, Purity ≥98%

Synonym: 379231-04-6; Bcr-Abl inhibitor; AZD-0530

MDL: MFCD09832698
CAS Number: 379231-04-6
Compound CID: 10302451

Product Size

10 mg; 25 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZD0530, soluble in warmed DMSO and ethanol and insoluble in water, specifically inhibits the activity of the Bcr-Abl tyrosine kinase. It targets c-YES, LCK, BLK, c-Kit, c-Src, CDK2, CSK, EGFR, EGFR (L858R), EGFR (L861Q), and EphA2.

Molecular Weight

542

Molecular Formula

C₂₇H₃₂ClN₅O₅

Targets

c-YES: 4 nM; LCK: <4 nM; BLK: 11 nM; c-Kit: 200 nM; c-Src: 2.7 nM; CDK2: 10 nM; CSK: >1 μM; EGFR: 66 μM; EGFR (L858R): 5 μM; EGFR (L861Q): 4 μM; EphA2: 236 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 34 mg/mL (62.73 mM); Water: Insoluble; Ethanol: 30 mg/mL (55.35 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZD0530 is utilized in research to target and inhibit Bcr-Abl tyrosine kinases, providing insights into mechanisms of leukemia treatment.