Properties
Description
BMS-354825, soluble in DMSO and insoluble in ethanol and water, specifically inhibits the activity of the Bcr-Abl tyrosine kinase. It targets Abl, c-Kit (D816V), c-Kit (wt), and Src.
Molecular Formula
C22H26ClN7O2S
Targets
Abl: 0.6 nM; c-Kit (D816V): 37 nM; c-Kit (wt): 79 nM; Src: 0.8 nM
Solubility
DMSO: 84 mg/mL (172.12 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
BMS-354825, known as dasatinib, inhibits Bcr-Abl and Src kinases in research focused on CML and other cancers.
