Bcr-Abl inhibitor Dasatinib monohydrate, Purity ≥98%

Synonym: 863127-77-9; Bcr-Abl inhibitor; BMS354825

MDL: MFCD08704581
CAS Number: 863127-77-9
Compound CID: 11540687

Product Size

500 mg; 1 g; 2 g; 5 g

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Dasatinib monohydrate specifically inhibits the activity of the Bcr-Abl tyrosine kinase. It targets Bcr-Abl, c-Kit, FGFR1, Her1, Her2, lck, MEK, p38, PDGFRβ, and Src.

Molecular Weight

506.02

Molecular Formula

C₂₂H₂₈ClN₇O₃S

Targets

Bcr-Abl: 1.0 nM; c-Kit: 5.0 nM; FGFR1: 880 nM; Her1: 180 nM; Her2: 710 nM; lck: 0.4 nM; MEK: 1700 nM; p38: 100 nM; PDGFRβ: 28 nM; Src: 0.5 nM; yes: 0.5 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

Dasatinib monohydrate is examined in lab settings to inhibit Bcr-Abl and Src family kinases, offering insights for chronic myeloid leukemia treatment.