Bcr-Abl inhibitor GNF 7, Purity ≥98%

Synonym: 839706-07-9; Bcr-Abl inhibitor; GNF7; GNF 7

MDL: MFCD18251569
CAS Number: 839706-07-9
Compound CID: 11478363

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GNF 7, soluble in warmed DMSO and insoluble in water and ethanol, specifically inhibits the activity of the Bcr-Abl tyrosine kinase. It targets c-Abl, E255V, G250E, M351T, and T315I.

Molecular Weight

547.53

Molecular Formula

C₂₈H₂₄F₃N₇O₂

Targets

c-Abl: 133 nM; E255V: 122 nM; G250E: 136 nM; M351T: <5 nM; T315I: 61 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 17 mg/mL (40.63 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GNF 7 acts on Bcr-Abl to study its application in hematological malignancies.