Bcr-Abl inhibitor GZD824 dimesylate, Purity ≥98%

Synonym: 1421783-64-3; Bcr-Abl inhibitor; GZD-824 Dimesylate

CAS Number: 1421783-64-3
Compound CID: 71519689

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GZD824 dimesylate, soluble in DMSO and water and insoluble in ethanol, specifically inhibits the activity of the Bcr-Abl tyrosine kinase. It targets Abl (E255K), bl (M351T), Abl, Abl(G250E), Abl(H396P), Abl(Q252H), Abl(T315I), and Abl(Y253F).

Molecular Weight

724.77

Molecular Formula

C₂₉H₂₇F₃N₆O.2CH₄O₃S

Targets

Abl (E255K): 0.27 nM; bl (M351T): 0.29 nM; Abl: 0.34 nM; Abl (G250E): 0.71 nM; Abl (H396P): 0.35 nM; Abl (Q252H): 0.15 nM; Abl (T315I): 0.68 nM; Abl (Y253F): 0.35 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 93 mg/mL (128.31 mM); Water: 93 mg/mL (128.31 mM); Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GZD824 dimesylate has a similar application, focusing on overcoming resistance in chronic myeloid leukemia.